| 전형방법 |
- Postdoc Position
University of Michigan, US
The Lubman Lab in the University of Michigan is looking for a passionate postdoc in the field of biology or chemistry. We are located in a beautiful and safe city Ann Arbor in Michigan, US.
Our lab is focused on the problem of cancer detection. In particular, we are working toward identifying biomarkers to enable the use of liquid biopsies. Strategies toward this goal include:
1. Glycoprotein Analysis in Serum: This includes quantification and structural changes to identify potential biomarkers. Mass spectrometry is being used to study site specific changes in glycan structure and its relationship to various cancers. We are also interested in studying the effects of isomeric forms of glycans on biomarker discovery. Mass spec methods include the use of stepped HCD, LC-EThcD and PRM for discovery and validation of biomarkers.
2. Isolation & Analysis of Exosomes: These lipid-coated vesicles are secreted and differentially expressed by all types of cells, including cancer cells. Exosomes contain nucleic acids, proteins, and glycoproteins, and represent another promising area of biomarker discovery with respect to cancer and other diseases.
3. Isolation & Analysis of Circulating Tumor Cells (CTCs): CTCs play a role in cancer metastasis, but their capture and analysis has proven challenging since they occur in very low numbers. Our laboratory works with a commercial partner to filter CTCs from blood so we can analyze them for protein content and surface markers of disease progression, particularly in later stages.
4. Single Amino Acid Variants (SAAVs): Common genetic variations in DNA nucleotides, known as SNPS, for single nucleotide polymorphisms, lead to proteins with SAAVs. SAAVs have been implicated in several diseases, including sickle-cell anemia and, we have detected hundreds of SAAVs in cancer cells and in serum.
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| 기타사항 |
- Our laboratory conducts proteomic analyses of cancer cell lines and cancer specimen to identify proteins/modifications/SAAVs related to the disease and that potentially may serve as biomarkers. For details, please visit our website: https://medicine.umich.edu/dept/surgery-research/research-strengths/cancer-tumor-biology/lubman-lab/research
You are expected to have:
1. Ph. D degree in Biology, Chemistry, or related fields,
2. Capacity to do independent research,
3. Passion for wet lab experiments,
4. Good English speaking and writing skills.
If you are interested, please send your CV and the contact information of two referees to Professor David Lubman via dmlubman@umich.edu
The post will close as soon as it is filled.
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