여름정기학술대회
2022여름초록
발표자 및 발표 내용
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주저자
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공동저자
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접수자
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Salbutamol and formoterol are
considered to have a stimulating effect on respiration and growth-promoting
action in athletes, so they were specified as a prohibited drug by the World
Anti-Doping Agency. Formoterol and Salbutamol were quantitatively analyzed to
prevent doping, but they exist as a pair of enantiomers and only the active
isomer is extracted and sold. Therefore, it is necessary to check which drug
was administered in accordance with the World Anti-Doping Agency's regulations.
However, in a reversed-phase column, it is difficult to analyze each drug due
to the characteristics of enantiomers, so the development of a qualitative
analysis method for chiral separation is required. Most of antidoping
laboratories have limited equipment and time, so the indirect method that can
be applied to the existing method among chiral separation methods is more
advantageous than the direct method that requires additional equipment and
setup. In this study, a qualitative analytical method using an indirect method
was developed, and we optimized derivatization conditions for the pH and
concentration of the triethylamine buffer, the concentration of the
derivatization reagent, and the reaction temperature. Optimized analytical
methods were validated for limits of detection, limits of identification,
linearity, matrix effects, and precision. The developed method can be used for
the analysis of other chiral isomers in urine and can also be helpful in the
study of qualitative analysis methods for various chiral drugs.
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