여름정기학술대회
2022여름초록
발표자 및 발표 내용
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Brief Oral Presentation 발표신청 |
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국가 |
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공동저자
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접수자
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Electrospray ionization-mass spectrometry (ESI-MS) is one of the most
powerful molecular identification techniques which enables us to measure the
mass-to-charge ratio (m/z) of analyte ions with less
fragmentation. However, ESI-MS is difficult to use in hardly ionized materials.
In many cases, ionization in ESI-MS can be achieved by the transfer of protons
or metal cations. Therefore, molecules with no protonation/deprotonation site,
or polar functional groups, such as polyaromatic hydrocarbons (PAHs),
fullerenes, metal clusters, and several more, are difficult to be detected in
ESI-MS. In this study, we have tried to use the solution containing solvated
electrons as an additional ionization reagent for ESI-MS. We successfully
obtained ESI mass spectra of molecules that are hardly ionized with proton
transfer by applying solvated electron solution. Compared to the other reducing
reagent, solvated electrons can provide a much higher reducing capability that
efficiently produces negatively charged molecules. Furthermore, several charge-reduced
molecules exhibit the aggregation behaviors distinct from those without
reductions. Representatively, stacked hemin dimers with and without reductions
show distinguishable collision cross section values in ion mobility
spectrometry, indicating that the molecular charges and their distributions
should have significant impact on the aggregation such as π-π stackings. This
work suggests a new method to ionize the molecules, which are known to be
poorly ionized, by transfer of electrons. Furthermore, this will benefit the
diverse studies on the charge-dependent aggregation behavior, since this can
provide a rational way to control the molecular charges of the analyte in the
ESI solution.
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