여름정기학술대회
2022여름초록
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Metabolic syndrome is a conglomeration of conditions that associate with type 2 diabetes and cardiovascular diseases. Most of disorders arisen from metabolic syndrome does not exhibit distinct symptoms. Thus, it is indispensable to discover the biomarker panel in order to evaluate the metabolic state. Liquid chromatography coupled with mass spectrometry has been widely used to quantify many different biomolecules including metabolites. However, the diversity in chemical structure as well as physical properties have hindered quantitative analysis of multiple metabolites. In this research, we developed a method to quantify 114 different metabolites, which are associated with metabolic syndrome, from mouse serum using liquid chromatography coupled with triple-quadrupole mass spectrometer system. The result from this research will be applied to generate a panel to indicate metabolic disorder.
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