겨울 심포지움
2018겨울초록
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High-fat diet (HFD), generally rich with saturated fats, induce obesity, cognitive impairment and neurodegenerative diseases. Lipids are known to be involved in variety of neuronal signals in brain, which is the most important and multifunctional organ. As chronic consumption of HFD causes celluar malfunctioning and insulin resistance in neurons of brain tissues, lipidomic analysis of HFD induced mouse brain tissues has attracted much attention.
In this study, nanoflow ultrahigh pressure LC-ESI-MS/MS was applied io investigate four different brain tissues from mice: cortex, hippocampus, hypothalamus, and olfactory bulb. Mice were fed with the various dietary schedules: 8 weeks - normal control (N), and weight gain (F), 16 weeks - normal control (NNN), weight maintenance (FNN), weight gain (NNF), and weight cycling (FNF). Lipids were extacted by modified Folch with MTBE/MeOH method and 359 lipids were identified from brain tissues. Quantitative analysis revealed that an HFD significantly pertubated the lipidome of all brain regions and diacylglycerols, known to be related with insulin resistance, increased. Furthermore, weight-cycling group (FNF) was proved to be more affected than weight gain group (NNF).
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