겨울 심포지움
2018겨울초록
발표자 및 발표 내용
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발표구분 |
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구두발표 | |
포스터발표 |
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국가 |
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공동저자
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접수자
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As lipids are involved with various biological functions such as energy storage, cellular signaling, and cell to cell interaction, they play key roles in cellular survival, proliferation, and death. These cellular processes are associated with cancer genesis pathways, especially to transformation, progression, and metastasis, suggesting the bioactive lipids are mediators of a number of oncogenic processes. In a recent lipidomics research, lipid analysis about cancer gains much interests, because each type of cancer has different carcinogenesis pathways. In this study, lipids of patient’s blood plasma sample from five different cancers (liver, stomach, lung, colorectal, and thyroid) were investigated in order to discover lipids that show significant difference among the groups and to find potential lipid biomarkers for each cancer. Blood plasma were extracted from each cancer patient using the modified Folch method with MTBE/methanol, and the extracted lipids were analyzed by nUPLC-ESI-MS/MS. A total of 243, 236, 239, 239, 239, and 225 plasma lipids from patients with liver, stomach, lung, colorectal, thyroid cancer, and controls, respectively, were characterized and statistically evaluated.
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