겨울 심포지움
2018겨울초록
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Coronary artery diseases (CAD) refers to a condition in which coronary arteries become narrow by accumulation of cholesterols, fats, and other substances. Narrow coronary arteries restrict blood flow to heart and may even cause a partial or complete blockage of coronary arteries. In blood system, cholesterols are transported by lipoproteins. High density lipoprotein (HDL) is known to transport cholesterols from the cells to the liver, which helps removing excessive cholesterols out of cells.
Flow field-flow fractionation (FlFFF) is separation technique according to size in a range of nano to micrometer. In this study, FlFFF was utilized to separate HDL and LDL from human plasma samples with CAD and for the proteomic and lipidomic analysis using nUPLC-ESI-MS/MS. Miniaturized asymmetrical flow field-flow (AF4) channel was coupled on-line to electrospray ionization mass spectrometry (ESI-MS) for a high speed separation of lipoproteins and for simultaneous analysis of apolipoprotein A-1 (ApoA-1) which is one of HDL proteins and known to be related with the transport of cholesterol. .
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