겨울 심포지움
2018겨울초록
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Lipids play important roles in various cellular processes such as membrane structure, signaling, and apoptosis. High-fat diet is known to cause obesity which is induced by excess amount of lipid accumulation in skeletal muscles. Especially, high fat diet increases the accumulation of triacylglycerol (TAG) which is an energy source in skeletal, leading to a th dysfunction of mitochondria further to induce insulin-resistance diabetes.
In this study, effect of high-fat diet on the lipid profiles of the two types of skeletal muscle tissues, gastrocnemius (Gas) and soleus (Sol), from mice were investigated by nanoflow ultrahigh pressure liquid chromatography-electrospray ionization-tandem mass spectrometry (nUPLC-ESI-MS/MS). Mice were grown with eight different diet programs including normal diet and high fat diet. Lipid from each muscle tissue were extracted by modified folch methods and a total of 269 lipid species were identifiedand quantified.
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