Preeclampsia(PE), one of the three most common causes of maternal death in the world, leads to serious social and emotional disorder characterized by phenomenon of an increase in the elderly pregnant women and a decrease of fertility rate. Until now, there is no cure other than delivery, so the importance of early prevention is increasing day by day. Regarding the study of PE, most of them were analyzed for genome and proteome in the maternal blood, but research on the placenta, especially the proteins directly involved in the mechanism, is insufficient. To identify specific markers of PE, we simultaneously analyzed global proteome in PE, other complications related to pregnancy, and the normal mother. Through global proteome analysis based on LC-MS/MS, about 7,800 proteins were identified from the placenta, and about 200 placenta - specific proteins were identified.