2026년
한국질량분석학회 여름학술대회 및 총회
2026. 08.19 (수) ~ 2026. 08.21 (금)
창원컨벤션센터(CECO)
초록검색
| 제목 | Phytochemical Profiling and Anti-inflammatory Potential of Dendropanax trifidus extracts: Insights from LC-MS/MS Metabolomics and invitro Assay |
|---|---|
| 작성자 | 유수정 (국립순천대학교) |
| 발표구분 | 포스터발표 |
| 발표분야 | 4. Medical / Pharmaceutical Science |
| 발표자 |
Soojung Yu (Department of Natural Cosmetics Science, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea) Eunyeong Jeong (Department of Natural Cosmetics Science, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea, AI Bio Autonomous Research, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea) |
| 주저자 | Soojung Yu (Department of Natural Cosmetics Science, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea) |
| 교신저자 |
Mina Lee (Department of Natural Cosmetics Science, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea, College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon, Jeonnam-Gwang) |
| 저자 |
Soojung Yu (Department of Natural Cosmetics Science, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea) Eunyeong Jeong (Department of Natural Cosmetics Science, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea, AI Bio Autonomous Research, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea) Seoyeong Jang (Department of Natural Cosmetics Science, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea) Duc Dat Le (Department of Natural Cosmetics Science, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea, College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon, Jeonnam-Gwang) Thinhulinh Dang (College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea, Honam Regional Future Drug Development Convergence Education & Research Division (BK21 FOUR),) Thientam Dinh (College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea, College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon Natio) Mina Lee (Department of Natural Cosmetics Science, Sunchon National University, Suncheon, Jeonnam-Gwangju 57922, Republic of Korea, College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Suncheon, Jeonnam-Gwang) |
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Dendropanax trifidus (Thunb.) Makino ex H. Hara is an evergreen tree native to East Asia that has long been used in traditional medicine, particularly to relieve pain, swelling, and inflammatory conditions. Bioassay showed that 80% and 100% EtOH extracts of D. trifidus young leaves and twigs strongly inhibited NO production induced by LPS-stimulated RAW264.7 cells, with inhibition rates of 25.97% and 92.07%, respectively, compared to those of untreated LPS at a concentration of 100 mg/mL. Additionally, we investigated the untargeted metabolomic analysis utilizing liquid chromatography-integrated tandem mass spectrometry (LC-MS/MS) associated with the GNPS platform. There are 32 metabolites annotated from the D. trifidus extracts produced by using different EtOH ratios (0%, 80%, and 100%), classified into groups of flavonoids, fatty acids, alkaloids, organic acids, and terpenes, along with other compounds. Findings from this study suggested the diversity of chemical composition and anti-inflammatory properties of D. trifidus. Therefore, D. trifidus has the potential to be developed into anti-inflammatory products in the future after confirming the inflammatory mechanism in higher-level activity experiments. |
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