2025년
한국질량분석학회 여름학술대회 및 총회
2025. 08.27 (수) ~ 2025. 08.29 (금)
부산항국제전시컨벤션센터(BPEX)
초록검색
| 제목 | Label-free Quantitative Proteomics with High Precision and Accuracy, Driven by Ultra-high Sensitivity MS/MS |
|---|---|
| 작성자 | 최도영 (SCIEX) |
| 발표구분 | 포스터발표 |
| 발표분야 | 1. Fundamental & Instrumentation |
| 발표자 |
Doyoung Choi (SCIEX KOREA) |
| 주저자 | Doyoung Choi (SCIEX KOREA) |
| 교신저자 | |
| 저자 |
Doyoung Choi (SCIEX KOREA) |
|
The ability to identify protein biomarkers and quantify them with high precision and accuracy is critical to the study of the mechanisms of disease. Data-independent acquisition (DIA) workflows using high-resolution mass spectrometry (HR-MS) have become highly utilized for proteomics research, providing qualitative and quantitative information on proteins and their impact on biological pathways. DIA methods are well-suited to label-free quantitation (LFQ) workflows, which have several advantages over other techniques utilizing protein/peptide labeling1 . However, MS sensitivity and quantitative dynamic range often limit the quantitative analysis of low-abundance proteins and peptides. This poster showcases the depth of proteome coverage and LFQ accuracy and precision using the high MS/MS sensitivity of Zeno SWATH DIA2 on the ZenoTOF 8600 system. |
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