여름정기학술대회
2022여름초록
발표자 및 발표 내용
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주저자
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공동저자
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접수자
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Environmental
phenols are important endocrine disrupting chemicals that can cause adverse
health effects to exposed individuals. To correlate exposures and potential
health implications, a comprehensive and sensitive analytical method covering
multiclass phenols in a single sample preparation and analytical run is
essential. However, to date, there is no comprehensive and sensitive method
available for multiclass phenols due to the concurrent ionization and
sensitivity problems of phenols in ESI. In this study, we investigate influence
of mobile phase compositions on concurrent ionization and sensitivity
enhancement of multiclass phenols in ESI and propose a comprehensive and
sensitive LC–ESI–MS/MS method covering various phenol classes (i.e.,
bisphenols, parabens, benzophenones, chlorophenols, and alkylphenols). The
proposed method, affected by 0.5 mM ammonium fluoride under methanol
conditions, allowed the concurrent ionization of all the phenol and was found
to dramatically improved the sensitivity of bisphenols and alkylphenols with
high pKa (9–11) and poor ionization efficiency. The present method combined
with dilute and shoot enabled us to simultaneously quantify 38 phenols with
good chromatographic behavior and sensitivity.
This
study was supported by an intramural grant from Korea Institute of Science and
Technology
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