여름정기학술대회
2022여름초록
발표자 및 발표 내용
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| Brief Oral Presentation 발표신청 |
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주저자
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공동저자
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접수자
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Lipids are a major class
of biological molecules and are essential structural components of cellular
compartments. Lipids play important roles in energy storage, intercellular
signaling, transduction, cell proliferation, and apoptosis. Lipidomic is used
in disease research because it shows changes in lipid profile compared to
healthy people. Such lipid profiling enables the discovery of novel biomarkers for
specific diseases. Therefore, in this study, we used nUHPLC-ESI-MS/MS method to
analyze at the molecular level the overall lipid metabolism alterations in
breast milk and progeny plasma of mice fed nano-plastics. An LC-MS/MS method
has been developed to simultaneously analyze in vivo quantities and three
medically important lipid groups (glycerolipids, sphingolipids and
phospholipids). Methods for lipid identification within the three groups were
constructed using external and internal standards. Lipids detected in breast
milk and plasma were quantified by multiple response monitoring (MRM) methods. In
this study, lipid alterations in breast milk and plasma lipid changes in
progeny were observed when polystyrene nano-plastics (PS-NP) were ingested. Since
then, the effect of lipid alterations on obesity in progeny was also observed. Lipid
alterations in biological samples can play an important role in understanding
various pathophysiological conditions and the described methods can be used to
evaluate and monitor lipid changes due to hazardous substances.
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