여름정기학술대회
2022여름초록
발표자 및 발표 내용
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Human leukocyte antigen (HLA) class I has more than 18.000 alleles, each of which binds to a set of unique peptides from the cellular degradome. Elucidation of relationship between HLA alleles and antigenic peptides is crucial for understanding immune responses in autoimmune diseases and cancers. In this study, we aimed to characterize the peptidome that binds to HLA-A*33:03. For the purpose, the HLA-A*33:03 monoallelic B cell line was analyzed using immunoprecipitation and liquid chromatography-tandem mass spectrometry (LC-MS/MS). As results, 1355 and 111 peptides were sequenced with 5 mg and 2 mg of W6/32 antibody, respectively. To our knowledge, this study represents the largest dataset of peptides associated with HLA-A*33:03.
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