여름정기학술대회
2022여름초록
발표자 및 발표 내용
| 소속 |
|
|---|---|
| 발표구분 |
|
| 포스터발표 |
|
| Brief Oral Presentation 발표신청 |
|
| Keyword |
|
주저자
| 이름 |
|
|---|---|
| 소속 |
|
| 국가 |
|
공동저자
| 공동저자 |
|
|---|
접수자
| 이름 |
|
|---|---|
| 소속 |
|
Background: KPS2004 is a newly synthesized
thiazole quinoline derivative. It has considerable biological activity.
Therefore, it can be inferred that it has the value of in-depth research. In this study, we
discussed its metabolic pathway in human liver microsomes (HLMs).
Methods: KPS2004 (20 µM) were incubated for 60
min with 1 mg/mL pooled HLMs in the absence or the presence of an
NADPH-regenerating system. And then, The non-specific CYP inhibitor SKF-525A(0,
10 and 50 µM) was co-incubated
with 1 mg/mL human liver microsomes for 60 min, and the effects on KPS2004
metabolism were observed.
Results: A total of 6 metabolites (M1-M6) were
found. The hydroxylation of four metabolites occurred at the six-membered ring,
one at the methoxy group and one at the 3-position of the nitrogen ethyl group.
It was also inhibited by a non-specific inhibitor of CYP ( SKF-525A ).
게시물수정
게시물 수정을 위해 비밀번호를 입력해주세요.
댓글삭제게시물삭제
게시물 삭제를 위해 비밀번호를 입력해주세요.