겨울 심포지움
2018겨울초록
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Alzheimer’s disease is known as a major cause of dementia and is known to be caused by the accumulation of amyloid-beta plaques in brain leading to dysfunction in cognitive abilities. Mild cognitive impairment (MCI) refers to a translational state between cognitive changes of normal aging and AD and it has been reported that up to 80% of MCI progressed to AD during 6 years. It is known that amyloid-beta, a major cause of Alzheimer’s disease, is affected by plasma lipoproteins. Thus, studying lipid changes within the lipoproteins of patients with mild cognitive impairments and Alzheimer’s disease is an important role in finding potential biomarker candidates.
In this study, lipids from human plasma samples of age-matched controls, patients with mild cognition impairment, and Alzheimer’s disease patients were analyzed. Lipoproteins were size-sorted by using asymmetrical flow-field flow fractionation and lipids which were extracted from the collected fractions of high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very-low density lipoprotein (VLDL) were quantitatively analyzed by using nanoflow ultrahigh-pressure liquid chromatography-electrospray ionization-tandem mass spectrometry (nUPLC-ESI-MS/MS). A total of 363 lipid species were identified and quantitation.
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